In this cohort study of 956 patients with head and neck squamous cell carcinoma (HNSCC), Liao et al examine the association of delayed treatment initiation with outcomes of overall survival and recurrence, analyze factors that are predictive of delayed treatment initiation, and identify specific reasons for delayed treatment initiation. They found that the optimal time to treatment initiation (TTI) threshold to differentiate overall survival was greater than 60 days. Patients with HNSCC with TTI exceeding 60 days had poorer survival rates and greater risk of recurrence. Graboyes and Hughes-Halbert provide an Invited Commentary.

Source